The (Second) Deadliest Virus

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  • 게시일 2023. 08. 07.
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    Few of the monsters that evolution created have been so successful at hurting us as the variola virus, responsible for smallpox. The carnage it caused was so terrible and merciless that it compelled humankind, for the first time, to act truly globally. It was one of the greatest wins of our species over the ancient powers of nature, all made possible by… cows.
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댓글 • 10K

  • @kurzgesagt
    @kurzgesagt  8 개월 전 +2366

    Continue learning about the fascinating world of biology with our Human Cell Poster, exclusively available here: shop.kgs.link/human-cell

  • @richardperhai8292
    @richardperhai8292 8 개월 전 +5848

    Saw an excellent cartoon about this. A kid asks his mother what the scar on her arm was "It's a scar from the smallpox vaccine." The kid asks why he doesn't have one and the mother replied "Because it worked."

    • @jujuria13
      @jujuria13 8 개월 전

      I hate anti vaxxers

    • @daniel-rs6wn
      @daniel-rs6wn 8 개월 전

      true. this iswhy ihate anti-vaxxers,they'dwant to send us back to those times because of their rebellious idiocy.

    • @user-bo5rv8je2s
      @user-bo5rv8je2s 8 개월 전 +348

      This is absolutely adorable

    • @coliander4180
      @coliander4180 8 개월 전 +46

      Deep

    • @jc13781
      @jc13781 8 개월 전

      The round scars on peoples arms are from the polio vaccine not smallpox

  • @TechBearSeattle
    @TechBearSeattle 8 개월 전 +5223

    Fun fact: Cowpox is where we get the word "vaccine." It comes from scholarly Latin "vaccina," which means "pertaining to a cow."

    • @milckshakebeans8356
      @milckshakebeans8356 8 개월 전 +70

      there is no good reason for that word to exist

    • @TheFiammator
      @TheFiammator 8 개월 전 +178

      Yes, it's currently used in Italian language as well

    • @jongyon7192p
      @jongyon7192p 8 개월 전 +84

      @@milckshakebeans8356 which word, cowpox? Do you prefer it to be split like "cow pox"? SMH my head

    • @milckshakebeans8356
      @milckshakebeans8356 8 개월 전 +20

      @@jongyon7192p ment "vaccina" in latin

    • @jongyon7192p
      @jongyon7192p 8 개월 전 +23

      @@milckshakebeans8356 cuz it kinda looks like another word?

  • @meatcrimes-42069
    @meatcrimes-42069 8 개월 전 +1599

    i just think calling non-immune cells “civilian cells” is really funny and perfectly descriptive

    • @akashboinpally9228
      @akashboinpally9228 8 개월 전 +25

      haha true

    • @paradox11111111
      @paradox11111111 5 개월 전 +13

      The moment I heard it I thought I'm adding that to my vocabulary lol

    • @paradox11111111
      @paradox11111111 5 개월 전 +7

      @@RepentandbelieveinJesusChrist5 nah bro it's the civilian cells doing their work as usual

    • @Tyranid_Hive_Mind
      @Tyranid_Hive_Mind 5 개월 전 +15

      ​​@@RepentandbelieveinJesusChrist5It's bots like these that make Christianity look like a joke

    • @nathanpierce7681
      @nathanpierce7681 5 개월 전 +10

      pathogens: tfym war crimes im just trying to propagate

  • @notleviathan855
    @notleviathan855 8 개월 전 +1014

    My great grandfather and grandmother ALWAYS talked about diseases back when they were young. Mostly comparing it to how well he have it now. Some of the stories from my grandfather include the smallpox hysteria, how his father somehow got it while out of the country, and died before even making it home to the US. When they had a vaccine for it, he talked about how he actually got choked up so that nobody would have to suffer that fate anymore. I've seen the wounds smallpox leaves, I couldn't imagine having to live with them.

    • @namantherockstar
      @namantherockstar 8 개월 전 +4

      Nutshell inspires me.. My parents said if i get 40K followers They'd buy me a professional camera for recording..begging u guys , literally
      Begging.

    • @saiasiqwertyuiop6443
      @saiasiqwertyuiop6443 8 개월 전 +7

      You already have 41K subs @@namantherockstar

    • @boombabitch
      @boombabitch 8 개월 전 +10

      @@namantherockstar40k now its 50k kids just lying to get subs

    • @DogDogGodFog
      @DogDogGodFog 7 개월 전 +6

      ​@@namantherockstarLmao did you really think this KRplusr's name is 'Nutshell'?? 😂

  • @hybredmoon
    @hybredmoon 8 개월 전 +4856

    Before my first deployment I received a small-pox vaccine. The medic used a small forked needle dipped in the vaccine to puncture the skin of my shoulder and wiggle it around a bit. The result was a necrotic lesion about the size of a half-dollar coin, a fever, and two or three days of body aches. I still have a scar on my shoulder from the inoculation site. I had ONE lesion and was in bed for 3 days feeling rough while my body fought a version of the disease that wasn't even effective against my species. I cannot IMAGINE the suffering that someone with an actual case of small pox must have endured. By the end, death must've been a sweet release. It's frightening to see the caliber of threat required to get humanity to work together.

    • @EvilAng3la
      @EvilAng3la 8 개월 전 +625

      Reading about the ways that some people died from smallpox is nightmare material. Some of the most severe cases would result in people having their skin sloughing off. Photos are also terrifying. I just wish I could personally thank all the people involved in making sure that I never, ever had to worry about catching this horrible disease.

    • @AaronShenghao
      @AaronShenghao 8 개월 전 +183

      May countries still administered the vaccine as late as the 90’s I have a scar from it too.

    • @d00mnoodle
      @d00mnoodle 8 개월 전 +148

      Were all of these issues because of the vacine or because the forked needle wasn't properly sterilized? Because that can also cause serious infections

    • @Okarabouzouklis
      @Okarabouzouklis 8 개월 전 +46

      ​@@d00mnoodleyea I was thinking that too

    • @user-op8fg3ny3j
      @user-op8fg3ny3j 8 개월 전 +7

      @@d00mnoodle same, I too want to know

  • @moaskarab
    @moaskarab 8 개월 전 +12598

    it's really so frustrating to see people in developed nations protesting vaccines. as someone in a developing nation, where people would do anything for access to such healthcare, it feels like we've truly learnt nothing from our history.

    • @vinsente6752
      @vinsente6752 8 개월 전 +929

      People are protesting against the covid vax, not all vaccines

    • @BurakkuHishou
      @BurakkuHishou 8 개월 전

      The problem was it became politicized, information became readily available, and knowledge became more widespread. The covid-19 vaccine was protested against because people were aware. They saw the Vaccine didn't really help anybody, caused more side effects than help, and really only became a tool for politicized control rather than an actual cure. The covid vaccine did not help anybody as people were still contracting the virus, and even showed worse side effects than those who didn't get it. Side effects like heart problems became apparent very quickly, but despite all these occurances, governments still restricted freedoms, stifled conflicting views, and profited themselves off the chaos instead of being a force for good.

    • @niceboiboinice9046
      @niceboiboinice9046 8 개월 전 +69

      fr

    • @eleethtahgra7182
      @eleethtahgra7182 8 개월 전 +301

      ​@@vinsente6752same difference. But...yeah...certain brand is dangerous...

    • @hdbrot
      @hdbrot 8 개월 전

      @@vinsente6752 There are people who oppose all vaccines.

  • @vanpet1993
    @vanpet1993 7 개월 전 +311

    My fathers grandmother survived this virus on her own. More than half the village died as she remembers it. Her mother, father and 8 other siblings died from it, she was the only one to survive. Fun fact, she never got sick of anything after this in her life and lived over 90 years.

    • @Turnpost2552
      @Turnpost2552 5 개월 전

      That isnt a fun fact. HER family died and she lived in place so that they are not forgotten.
      Please vaccinate

    • @adamnesico
      @adamnesico 5 개월 전 +18

      She was the only survivor of 9?
      My dads little brother is too the only raven haired of the 9 siblings. Everyone knows he is illegitimate.
      So... I think she owes her life to the resistance genes of her biologic father.

    • @vanpet1993
      @vanpet1993 5 개월 전 +16

      @@adamnesico It happen more than 100 years ago so idk for sure. 😂 Could also be some recessive genes that others from her family didn't get...

    • @MissSweetie
      @MissSweetie 2 개월 전 +4

      she was the one human that got the genetic mutation to beat variola

    • @machineshot829
      @machineshot829 13 일 전

      luck

  • @FueledByDaria
    @FueledByDaria 5 개월 전 +162

    What a timely video to pop up on my feed today. I just took my 1-year old for her 12 month vaccines this morning (mumps, measles, rubella) and my heart broke hearing her cry from the shots. But I know that it’s necessary for her protection and I’m so grateful we can protect our children!

    • @Steel9k
      @Steel9k 5 개월 전

      Ehhhheh..
      Do you have FACTS that show the efficacy and safety of that MMR vaccine?
      Factual, unbiased facts I mean. : )
      Do you know about the kids who died due to effects of MMR vaccines, or suffered severe consequences, permanent damage to their health? O_o
      Why would MMR vaccination necessary for her protection?
      How can you "protect" your children? From what? How does that "mytical" protection work? What are the efficacy and safety levels of that protection? o__O

    • @The_Epicness9000
      @The_Epicness9000 5 개월 전 +11

      @@Steel9k 1. First link in the description.
      2. Far far, far fewer, both in raw numbers and rate-adjusted percentages, than the kids who died or got permanent health issues of measles, mumps, and/or rubella.
      3. Kurzgesagt has a video on how vaccines work.
      4. Better than 80%, and even that may be lowballing it.

    • @Steel9k
      @Steel9k 3 개월 전

      @@The_Epicness9000
      ". First link in the description."
      No, no real evidence that would be adequate in the description.
      Its the same old provax propaganda and lies.
      "2. Far far, far fewer, both in raw numbers and rate-adjusted percentages, than the kids who died or got permanent health issues of measles, mumps, and/or rubella."
      Yeah, because of manipulation of statistics and due to better living conditions, better nutrition, fresh water etc. Not due to vaccinations.
      "3. Kurzgesagt has a video on how vaccines work."
      A propaganda video, containing lies and not talking about the severe side effects vaccines cause.
      "4. Better than 80%, and even that may be lowballing it."
      You could just say ~ 4000 %
      If you lie, do it proudly :D

    • @masterofdoots5965
      @masterofdoots5965 개월 전 +7

      ​@The_Epicness9000 what did Steel9k say? Their comment is gone

    • @prashank
      @prashank 개월 전

      ​@@masterofdoots5965 i gather something super fooking dumb

  • @indisputable3
    @indisputable3 8 개월 전 +4194

    "The human body has adapted countless defense mechanisms that can completely exterminate any intruders"
    Variola: Hold my 200 genes

    • @iluvpandas2755
      @iluvpandas2755 8 개월 전

      Most anti-immune tactics are about tricking the immune system because it is not intelligent or sentient.

    • @iluvpandas2755
      @iluvpandas2755 8 개월 전 +145

      If it responds based of preprogrammed instructions and chemical ones you can easily trick it, sadly.

    • @rizzlerrickio
      @rizzlerrickio 8 개월 전 +74

      I love science humor 😭

    • @micah3807
      @micah3807 8 개월 전

      Yeah the immune system arms race is absolutely nuts. Basically, viruses (and to some extent bacteria) evolve so much faster than us that our immune system gave up and said "ok but whatever doesn't kill us will never be able to hurt us again" and rolled 30 thousand dice. with the obvious shortcoming that all a pathogen needs to do is kill us the first time.

    • @helloyes2288
      @helloyes2288 8 개월 전 +159

      @@iluvpandas2755 It does and doesn't. The adaptive immune system has the capacity for somatic hypermutation. Regions of your DNA that purposefully rip themselves apart and recombine to form new antibodies and the space of possible variant targets is extremely large. It's a programmed process but it allows the immune system to target things it isn't programmed for.

  • @Ratharian
    @Ratharian 8 개월 전 +1841

    The revelation came when doctors noticed milk maids didnt get small pox and most farmers showed immunity as well. So when they looked at cowpox, they realized small pox had the same markers, so immunity to one meant immunity to the other.

    • @rehanhossainalim6038
      @rehanhossainalim6038 8 개월 전 +9

      Markers? Dont you mean proteins?

    • @Darkcamera45
      @Darkcamera45 8 개월 전 +73

      @@rehanhossainalim6038yes same thing probably just different words

    • @Bobbhgf
      @Bobbhgf 8 개월 전 +7

      It was Edward Jenner

    • @bananaeclipse3324
      @bananaeclipse3324 8 개월 전 +52

      @@rehanhossainalim6038pretty sure by markers he means symptoms. Around that time they wouldn’t have been able to see exactly how viruses ticked and so symptoms would be the way they could tell the difference.

    • @Wingyy1995
      @Wingyy1995 8 개월 전 +26

      @@Bobbhgf yup he was variolated , one of his teachers (?) was also a milkmaid and said "that's ok, but i had cow pox so I can't get small pox" and that sentence basically set up his life's dedication to the disease

  • @iloveplasticbottles
    @iloveplasticbottles 8 개월 전 +51

    Smallpox: *tries to infect my vaccinated ass*
    My antibodies: pull up bro

    • @aste4949
      @aste4949 개월 전

      Lucky! Alas, smallpox vaccines stopped being routinely given after eradication was declared. I was born far too late to get it, so I hope smallpox never leaves the labs!

    • @netheritemythril2766
      @netheritemythril2766 개월 전 +4

      Science humor is the best 😂

  • @psyOmicron
    @psyOmicron 7 개월 전 +63

    Virologist postdoc here! Just wanna thank you on your excellent video on smallpox and Edward Jenner! Know that your video is used to educate future immunology undergrads.
    Can I suggest Poliovirus next? It's just a really interesting disease/virus with real life visual social impacts like iron lungs and kids in crutches.

  • @CMVBrielman
    @CMVBrielman 8 개월 전 +9242

    It is worth noting that Smallpox was the *ideal* virus to eradicate. Its particular traits made it extremely deadly but also extremely easy to target by coordinated vaccination efforts. Most other viruses are nowhere near so considerate.

    • @foolishball9155
      @foolishball9155 8 개월 전 +352

      All viruses are easy to target except for ones with extremely long incubation period since most viruses are extremely host specific

    • @RipRLeeErmey
      @RipRLeeErmey 8 개월 전 +611

      ​@@foolishball9155 It's a bit of a double edge sword; yes, lot of viruses are host specific and therefore are easily detectable. However, viruses also rapidly evolve thanks to how easy it is for mRNA (the chemical method by which a virus hijacks it's host) to mutate due to the lack of proofreading proteins. These mutations could very easily give viral offspring immunities that it's parents never had the luxury of having.
      That and while we have one or two kids that take 18 years to mature, viruses have multiple hundreds of progeny that mature seconds after they're born; they just evolve way faster than we do out of sheer numbers

    • @squeaksquawk4255
      @squeaksquawk4255 8 개월 전 +350

      IIRC the main 2 factors were that it was human-only, and that symptoms showed BEFORE it was contagious

    • @randomconstructions4513
      @randomconstructions4513 8 개월 전 +1

      @@foolishball9155 Most of the viruses that you commonly get (cold flu and our newest friend the coronavirus) are able to infect a large portion of at least the mammals(ebola and some other nasty stuff would fall into this too, even things that aren't viruses like anthrax, malaria, and the plague). As an additional problem many viruses effectively prevent the immune system from detecting them or normally functioning (HIV, Hepatitis C) which further complicates the issue.
      Viruses that we could reasonably have a chance at eradicating would be polio... maybe the viral Hepatitis depending on how much we reduce the price of the magic pill?
      Without further technical advancement in either genetic modification, or medical technology (wide band virophages or something) most RNA viruses will be uncontrolled (due to their modification speed) along with those that have a wide spectrum of hosts.

    • @foolishball9155
      @foolishball9155 8 개월 전 +93

      @@RipRLeeErmey yeah it is true that RNA viruses evolve way faster than DNA viruses. There are more DNA viruses but most of them are not deadly disease except the ones that cause cancer like HPV. My point does not hold much water in case of highly mutatable viruses.

  • @Harsh-kp4md
    @Harsh-kp4md 8 개월 전 +3139

    If you didn't knew , the last person to die from small pox was Janet Parker. In 1978, Parker was a medical photographer at England's Birmingham University Medical School. She worked one floor above the Medical Microbiology Department where staff and students conducted smallpox research.

    • @JokeswithMitochondria
      @JokeswithMitochondria 8 개월 전 +228

      Poor girl

    • @sterlingarcher8041
      @sterlingarcher8041 8 개월 전 +121

      @@JokeswithMitochondria l was curious about ur usernamee so cIicked on ur profiIe. Wasn’t disappointed lol

    • @taiwanluthiers
      @taiwanluthiers 8 개월 전

      Smallpox is often the reason why people used to have 10 babies, with the expectation that a few will make it to adulthood. People asked how did ancient people live without vaccines, the answer was, they didn't. They just had more babies so more could die without wiping out humanity. Look at cemeteries from the 1800s and you will see a lot of children's graves.

    • @Jojojjojojojo
      @Jojojjojojojo 8 개월 전 +34

      Now I wonder why she wasn't vaccinated

    • @Astrosk1er
      @Astrosk1er 8 개월 전

      Probably for similar reasons as the idiots today

  • @stephensusman36
    @stephensusman36 7 개월 전 +79

    Big fan of you guys! You all played a role in me deciding to become a biochemistry major and later go into medicine to be a doctor! Just graduated from med school, in my medicine residency, and I still love watching the videos you make! Keep up the good work! (And of course your soundtrack music on Spotify has been a large part of my study background music this entire time!) Excellent work!

  • @gabrieleprosperi692
    @gabrieleprosperi692 8 개월 전 +107

    I began to be so sensitive to those topics, and the way (at the and of the video) you talked of the light of vaccines, that i almost cry every time. The topics like cancer and viruses are very important to me since the death of my uncle (April). I study natural science in university and i want to tank you for all the amazing things you spread on the web. Things that normally i heard At uni.

  • @janmelantu7490
    @janmelantu7490 8 개월 전 +353

    The greatest opening words of a Wikipedia article are “Smallpox was”

    • @oightKoreraAreEditable
      @oightKoreraAreEditable 8 개월 전 +13

      Reminds me of Exurbia's video

    • @seecresy
      @seecresy 8 개월 전 +4

      ​@@oightKoreraAreEditablewas about to comment about it

    • @oightKoreraAreEditable
      @oightKoreraAreEditable 8 개월 전 +1

      @@seecresy oh sorry didnt see the reply, the video? "Misery was" if irc!
      If you mean who I was replying to, I was just replying to the comment itself!

  • @hishamrashid5293
    @hishamrashid5293 8 개월 전 +1409

    In case you all were wondering, the cow that had cowpox was named Blossom.😊

    • @JokeswithMitochondria
      @JokeswithMitochondria 8 개월 전 +69

      How cute

    • @sterlingarcher8041
      @sterlingarcher8041 8 개월 전

      @@JokeswithMitochondrial I was curious from ur usernamee so cIicked on ur profiIe. Wasn’t disappointed lol

    • @badbunnyky
      @badbunnyky 8 개월 전 +40

      is ur icon supposed to make ppl think they have a hair on their screen.

    • @Listenimtooshyalright
      @Listenimtooshyalright 8 개월 전 +15

      @@JokeswithMitochondriaI got curious about ur username so clicked on ur profile. Wasn’t disappointed lol

    • @circuit10
      @circuit10 8 개월 전 +20

      @@ListenimtooshyalrightI saw an extremely similar interaction to this on an unrelated video, I think these two users might be bots? Or at least one person

  • @liyuan2654
    @liyuan2654 4 개월 전 +13

    I watched this video then watched the cancer one, and it just makes me think how this disease could’ve just been the “cancer” in the past. And it’s even more unbelievable to think that even cancer could be eliminated in the future! Incredible.

  • @garg4531
    @garg4531 8 개월 전 +34

    "We are still protected by the light, but it is cooling each and every day, and we it to those who will come after us to make sure it doesn't go out. We killed one monster. We can do it again."
    Wow, that was inspirational

    • @arminkaiser8933
      @arminkaiser8933 6 개월 전

      "Open Philantrophy" foundation funded this video, of course they`ll use lurid phrases to advertise furture vaccines.

  • @whisper3856
    @whisper3856 8 개월 전 +1811

    Smallpox being eradicated is probably one of the largest achievements humanity has ever done, at least in my opinion. It gives me so much pride in humanity to know that we have eradicated it.

    • @Griefing594
      @Griefing594 8 개월 전

      Yeah well, there’s still other diseases, much, much more terrifying than smallpox

    • @Luke_Sandy_High_Ground
      @Luke_Sandy_High_Ground 8 개월 전 +128

      Now if only we can eradicate Tik Tok

    • @sakuseihuoshen
      @sakuseihuoshen 8 개월 전 +57

      ​@@Luke_Sandy_High_GroundReally wish it'd get banned, not only is it disruptive it's also making the next generation's attention span go at an all-time low. 😔

    • @EricV-lq3jq
      @EricV-lq3jq 8 개월 전 +51

      Really doesn't matter, let people have fun. Drug, crime, immagration, and war crisises and your worried about people watching 10sec vids over 10min??

    • @crazyluigi6664
      @crazyluigi6664 8 개월 전 +11

      *COVID-19@@Luke_Sandy_High_Ground

  • @mustwereallydothis
    @mustwereallydothis 8 개월 전 +2454

    I had a friend at school in the 70s who had suffered smallpox as a baby. She was one of the final few people in our country to have it. Fortunately, her face, hands and neck only had a few mild scars. The scarring on her arms was shocking. I never saw the rest of her body.

    • @Christopher-qq4dl
      @Christopher-qq4dl 8 개월 전 +28

      Lol

    • @danielyaseen
      @danielyaseen 8 개월 전 +340

      @@Christopher-qq4dlwtf

    • @RandomUserXD
      @RandomUserXD 8 개월 전 +6

      Thankfully he had the Variola Minor

    • @jmneo4635
      @jmneo4635 8 개월 전 +67

      The Scarring is real and I still have scars on my chest and below the neck and even one fairly small but noticeable bump on my neck.

    • @namantherockstar
      @namantherockstar 8 개월 전 +9

      Nutshell inspires me.. My parents said if i get 40K followers They'd buy me a professional camera for recording..begging u guys , literally
      Begging.

  • @AquaticWaffels
    @AquaticWaffels 7 개월 전 +32

    I’m a college student right now taking biology but I don’t know what I want to specialise in, this video honestly inspires me to pursue microbiology and eventually research diseases

    • @The-one-and-only-Fruitcake
      @The-one-and-only-Fruitcake 7 개월 전 +2

      Same here! Between this channel and Snake Discovery, I’m split between microbiology and herpetology. I might just go with both, honestly

    • @MasterMagikarp
      @MasterMagikarp 6 개월 전 +2

      I hope everything goes well wether you end up pursuing microbiology or not

    • @Josh350
      @Josh350 2 개월 전 +1

      Microbiology emphasizes in microbes. Virologist focus on viruses.

  • @tysonnm5034
    @tysonnm5034 4 개월 전 +8

    the erradication of smallpox is a prime example of just what humans are capable of, and that we are capable of working together. You can be pessimistic, but i think humans are still capable of massive species wide feats like this.

  • @majkon93
    @majkon93 8 개월 전 +2391

    The successful international effort during the 1960s to eradicate smallpox was headed by Czech physician and epidemiologist Karel Raška. His new concept of eliminating the disease was adopted by the WHO in 1967 and eventually led to the eradication of smallpox in 1977. Raška was also a strong promoter of the concept of disease surveillance, which was adopted in 1968 and has since become a standard practice in epidemiology.

    • @bichtran2539
      @bichtran2539 8 개월 전 +4

      ok

    • @AnonYmous-yu6hv
      @AnonYmous-yu6hv 8 개월 전 +1

      Yet covid got out

    • @frozenfeet4534
      @frozenfeet4534 8 개월 전 +68

      @@tafazzi-on-discord weird how the people 'making everything about race' are reactionaries like you

    • @sylvanusblimpo154
      @sylvanusblimpo154 8 개월 전 +7

      It’s because of the things that they have gone through. Ever been a slave? Don’t think so.

    • @milferdjones2573
      @milferdjones2573 8 개월 전

      @@tafazzi-on-discord Maybe or the Wet Market the Chinese have made telling for sure very hard and we might never know. We do have to find the source animal still as it was not a purely lab created virus I don't even know if we have ever made one of them even.
      The Lab is accused of taking an existing virus and making it worse to test things. But this process happens in Nature it how all the virus that hit us in the past were created.
      Total funding unknown but China standard does not let outsiders control anything and insists on having part of the pie themselves. Outsiders get to make suggestions that are followed or not depending on the Chinese they don't have the legal power to force anything.
      So any lab error was in part China's and failure to shut the City down quick is their flaw as well assuming it even came from there the virus was found at both locations.

  • @irishpolyglot
    @irishpolyglot 8 개월 전 +233

    The cowpox virus was also known as "vaccinia" from the Latin "vacca" for cow. Since actual cowpox was used to "vaccinate", it's where the word vaccine comes from in the first place!

    • @Threedog1963
      @Threedog1963 8 개월 전

      Cool info. I like trivia stuff like that.

    • @billypilgrim1
      @billypilgrim1 8 개월 전 +12

      Something so obvious and yet something I had no idea about. In Spanish vaccine is "vacuna" which is even closer.

    • @vice.nor.virtue
      @vice.nor.virtue 8 개월 전 +2

      Funnily enough the first serial killer to be identified asuch in the 1970s was from _Vaccaville, CA_ and his name is Ed Kemper

    • @derpz_
      @derpz_ 8 개월 전 +2

      Yes, I wonder how it did not fit in the video

  • @sakshamverma1369
    @sakshamverma1369 8 개월 전 +12

    Apart from everything else the animation is so well done. Explains everything at such ease and in a fun and thrilling way! Hats off!

  • @UnsettledSoldier
    @UnsettledSoldier 8 개월 전 +3

    Gorgeous cell designs. I will also never get tired of this channel’s art style

  • @OhhCrapGuy
    @OhhCrapGuy 8 개월 전 +1186

    When I was growing up, my family had a World Book encyclopedia from 1974, and later got ahold of one from 1982. As some of us do, I went through that weird phase where you get fascinated by diseases, and I was fixated on Smallpox. It just so happened that this coincided with us getting the newer version of the set.
    At the time, I just thought it was funny that the older one was "wrong" since smallpox had been eradicated and it was out of date.
    But one of the things I noticed at the time, which is truly striking today, is that the first sentence in the different editions were nearly identical, except that the second had one miniscule difference. It had a most terrible word replaced with a most lovely one.
    "is" had become "was"

    • @Burn_Angel
      @Burn_Angel 8 개월 전 +43

      That last bit reminds me of a Vsauce video from some years ago.
      Edit: nope, it was an exurb1a video, I'm dumb haha.

    • @JokeswithMitochondria
      @JokeswithMitochondria 8 개월 전 +10

      Smallpox was scary

    • @trumpputinkim
      @trumpputinkim 8 개월 전

      @@JokeswithMitochondriaur userrname got me curious and I cIicked on ur profiIee. Was not dissappointed ahaha

    • @therealspeedwagon1451
      @therealspeedwagon1451 8 개월 전 +28

      It’s truly amazing when such a terrible disease that *was* the scourge of humanity for countless millennia becomes a was. But it’s also terrifying that to an extent it still exists. Not just in token laboratories, but frozen in Siberian permafrost, waiting to melt and unleash it’s horror on the world again.

    • @francovlla
      @francovlla 8 개월 전 +6

      Wow so deep. Then everyone clapped alongside exhurbia

  • @Kristina-ek8yt
    @Kristina-ek8yt 8 개월 전 +653

    In 1972, Yugoslavia had an outbreak of smallpox, it was the largest outbreak in Europe after the Second World War. I recently read about it, very fascinating! They vaccinated eighteen (18) million citizens in about one month.

    • @4kta
      @4kta 8 개월 전 +13

      Da, takođe i Srbija ima taj virus u labaratoriji obezbeđen. Yes, Serbia also has a sample of it secured in a lab.

    • @NoName-hg6cc
      @NoName-hg6cc 8 개월 전

      ​@@4kta you mean vaccine right? RIGHT?
      Serbia shouldn't have sample of the virus

    • @wearefromserbia9714
      @wearefromserbia9714 8 개월 전

      @@4kta ima se, može se

    • @Deboned_butter
      @Deboned_butter 8 개월 전 +13

      @@4ktaYup. There are two places where the virus is still contained as the video said.
      The one one in Siberia, and the one in the USA.
      Edit: Siberia, not Serbia… lol

    • @user-cx2kv5sd2j
      @user-cx2kv5sd2j 8 개월 전 +4

      @@Deboned_butter No, it's in Russia not Serbia

  • @jo_crespo11235
    @jo_crespo11235 8 개월 전 +2

    Great vid, congrats to the team behind, keep the hard work.

  • @LightBringer127_dragonart

    Thanks for linking the video by Rational Animations. I never would have discovered the channel otherwise

  • @TimeBucks
    @TimeBucks 8 개월 전 +1300

    Smallpox is truly the stuff of nightmares

  • @dismotherefer
    @dismotherefer 8 개월 전 +147

    The line "we killed one monster. We can do it again." Is so metal. Fantastic.

    • @ShadeAKAhayate
      @ShadeAKAhayate 8 개월 전 +6

      Too bad it's not really that simple with total most of other viruses even if 'we' have had such a wish. Even worse is 'we' don't have such a wish and a large part of 'us' is actively fighting this tendency.

    • @timewave02012
      @timewave02012 8 개월 전

      @@ShadeAKAhayate When "we" also create scarier monsters to get better at killing them, and the people who create the monsters supposedly find one in the wild that looks like one they would have created, and the media censors, ridicules, or slanders the people who point this out, then yeah, you're going to get people fighting it, even if every part of the process is in the best interest of the people fighting it.

  • @natetheavali784
    @natetheavali784 4 개월 전 +3

    My grandma actually was really happy when smallpox was eradicated, as well as when the polio vaccine came out. She got polio as a kid and lost some hearing, so hearing about diseases getting thrown out the metaphorical airplane window makes her happy

  • @AstroNUT24
    @AstroNUT24 7 개월 전 +1

    love your videos! always masterpieces 🔥

  • @SpeedOfDarknesss
    @SpeedOfDarknesss 8 개월 전 +99

    Fun fact:
    The word "vaccination" comes from the Latin word for cow "vacca"😊

  • @Puzzl3
    @Puzzl3 8 개월 전 +962

    Its Crazy how a what was a small passion project is now one of the biggest science outlets in KRplus
    Keep it up!

    • @namantherockstar
      @namantherockstar 8 개월 전 +8

      Nutshell inspires me.. My parents said if i get 40K followers They'd buy me a professional camera for recording..begging u guys , literally
      Begging...

    • @miji6267
      @miji6267 8 개월 전 +54

      ​@@namantherockstarwork. Saving up for the camera. It would teach you something.

    • @959_MC
      @959_MC 8 개월 전

      @@miji6267 just report the comment, its a generic spam account. (Ive seen this same comment with the name altered spammed on like 10 different channels)

    • @aamirrazak3467
      @aamirrazak3467 8 개월 전 +4

      Yeah kurzgesagt is awesome it’s great how it became such a popular and significant channel from a humble start

    • @andreiiimiguel
      @andreiiimiguel 8 개월 전 +2

      i loved them from the start🥹, im glad im still here

  • @Campaigner82
    @Campaigner82 5 개월 전

    Cool episode! I really like that you made the virus look and SOUND evil.
    The scene where it went though time and murdered civilizations…..love your animations! Keep at it!

  • @romin7255
    @romin7255 17 일 전

    Well told, and very well illustrated...
    Thanks.

  • @iamcrash5525
    @iamcrash5525 8 개월 전 +437

    Hearing something so deadly get eradicated will never not be satisfying to hear

    • @Leyrann
      @Leyrann 8 개월 전 +45

      It is far less talked about, but in my opinion, the eradication of smallpox is a human achievement on par with the moon landing or the internet. Arguably beyond them.

    • @matthewcurry3565
      @matthewcurry3565 8 개월 전

      I got some unfortunate facts about human behavior if you feel that way.

    • @Lumberjack_king
      @Lumberjack_king 8 개월 전 +2

      ​@@Leyrannabsolutely it's the greatest thing our species has accomplished

    • @emikochan13
      @emikochan13 8 개월 전 +2

      @@Leyrann several of the people that got us to the moon or internet probably would have died to smallpox for sure.

    • @angelofamillionyears4599
      @angelofamillionyears4599 8 개월 전 +1

      None of these clowns on this channel are Drs !! They even admit it !! We’re a team of illustrators, animators, number crunchers and one dog who aim to spark curiosity about science and the world we live in. To us nothing is boring if you tell a good story. Read the # 1 Best selling book VIRUS MANIA- written by a real Dr. !!Thanks

  • @deoxi3207
    @deoxi3207 8 개월 전 +387

    I love how these cells are refered to as civilian cells, immune cells (military cells) and heavy weapon cells. It really does bring home the fact that the whole body is a whole community working side by side to ensure the continuation of the whole. The only reason why the body would kill cells in itself would be if the cells did harm to the overall system and there was no better way to deal with the matter.

    • @milferdjones2573
      @milferdjones2573 8 개월 전

      Unfortunately the body in some areas like this one can be tricked into killing it's own cells.

    • @de0509
      @de0509 8 개월 전 +7

      Didnt know cells also do immune cell brutality

    • @trololkhil9868
      @trololkhil9868 8 개월 전 +33

      there's a lot more roles...you have engineer cells (cd4 helper cells->th1/th2), comms/scouting/foe recognition cells (dendritic cells), interrogation/patrol cells (macrophages/follicular dendritic cells), discipline cells (IL10/cd25 cells), 'automated terminator/robotic division' cells (nk cells), caretaker cells (microglia), heavy weapon/ballistic/grav mines (b cells), self assembly nanobot attacks (complement/MAC), builder/repair cells (platelets), education/teacher cells (mtecs). It's nothing short of awe inspiring the degree of specialisation/flexibility our body has.

    • @turbo8628
      @turbo8628 8 개월 전 +12

      The cells in our bodies evolved before joing together for survival purposes (multi-celled organism as opposed to single-cell).
      Through cooperation, despite their differences, they feed and defend eachother. Ironic that humans as a species often discriminate against anyone not belonging to their "tribe" when this mass diversity of cells is what holds all of us together. Poetically though, you could argue that multiculturalism and tolerance resides in all of us as we are literally made of these qualities.

    • @gabrielpineirogarcia2078
      @gabrielpineirogarcia2078 8 개월 전 +6

      @@trololkhil9868 when I studied It in Biology I was in awe at the level of organization the inmune system has with the body. It makes me wonder if how we organized our society where people specialize in a task, is evolutionary emergent from the same system that makes our bodies work like this

  • @SAwfulEPM
    @SAwfulEPM 8 개월 전 +3

    Us early-90s kids will hopefully be the last who went to "chickenpox parties", which was less variolation and more "let's get it over with", and left the virus in our spinal cords like time bombs to turn into Shingles someday. Now there's a direct vaccination for it instead, no time bombs in the spine necessary.

    • @NoName-hg6cc
      @NoName-hg6cc 8 개월 전

      Exactly

    • @jarskil8862
      @jarskil8862 8 개월 전 +1

      Never got chickenpox as kid. For adult it can be way more dangerous so was happy to get the vaccine.

    • @Steel9k
      @Steel9k 8 개월 전

      As a 90's kid, I don't have 'time bombs' in my body from the mentioned infection.
      However I do have serious concerns regarding the chickenpox vax.
      Efficacy, safety related, and additionally other concerns.
      What ignorant provaxers don't really care above.

  • @hanuchan
    @hanuchan 8 개월 전

    I remember learning about this in a lecture. Awesome video!

  • @LarvaTubaShow
    @LarvaTubaShow 8 개월 전 +913

    Amazing how from such humble beginnings and human cooperation, we were able to eradicate an entire disease. It’s inspiring, hope we can unite like that more in the future

    • @Jukajobs
      @Jukajobs 8 개월 전 +37

      We're pretty close to eradicating dracunculiasis, which is caused by the guinea worm, a parasite. Apparently there were only 13 reported human cases in 2022! And that's despite of the lack of vaccines or very effective treatments for it. Plus, it can infect animals too, which makes it harder to eradicate, but animal infections have also gone way down. Humankind went from millions of cases back in the 80s to extremely few these days. It isn't nearly as deadly as smallpox was, but it's disabling, and can facilitate infections with other diseases. It's not as well-known because it's generally more present in parts of the world that tend to get less international attention, but it's a big deal, and hopefully we'll be able to end it in the next few years.

    • @Glamerth
      @Glamerth 8 개월 전

      Yeah but it took 200 years AFTER the cure was invented to actually eradicate the disease. Half a billion people from smallpox died because of profits. This is glossed over in the video

    • @HealyHQ
      @HealyHQ 8 개월 전 +57

      I wish humanity would come together more often. We have so much potential, and it's all wasted because of competition and in-fighting amongst the human race. Truly depressing.

    • @jongyon7192p
      @jongyon7192p 8 개월 전 +50

      Yeah it's inspiri--
      Antivaxxers:

    • @ShadowEclipse777
      @ShadowEclipse777 8 개월 전

      ​​​@@jongyon7192pseriously. I doubt we could have eradicated covid, (far too infectious) but I know it would have been possible to prevent it from becoming endemic across the world had there not been large amounts of interference towards control measures by the ignorant and selfish. We got lucky that it kept mutating to be less severe over time

  • @macgopal4882
    @macgopal4882 8 개월 전 +36

    Imagine being a literal killing machine and getting defeated by apes with pointy needles 8:37

  • @omegaman968
    @omegaman968 7 개월 전

    The animations are brilliant as always

  • @swabrahamalnakalembe9194

    Thank you for making this very interesting to learn. This is really informative and educative in the most fun way.🎉

  • @APG19912009
    @APG19912009 8 개월 전 +486

    Thank you Edward Jenner!!!
    For noticing the Cow pox and the cow maids who never got small pox. He had a scientific hypothesis and was able to replicate it and gave us one of the greatest discoveries in human history!
    My parents have their smallpox vaccination scar. And I remember as a kid asking what it was, because I didn’t have one…and why I didn’t need one.

    • @kagitsune
      @kagitsune 8 개월 전 +25

      Considering how much we're letting our vaccination campaigns wane, now I want to take a few days off and get one!!

    • @Ak_u_
      @Ak_u_ 8 개월 전

      Edward Jenner was a menace, he infected his son with cow pox, and to prove his hypothesis then proceeded to infect his son with the real virus. Luckily, his hypothesis was true

    • @MegaBanane9
      @MegaBanane9 8 개월 전 +32

      Fun fact: the cow maids never getting it is also the reason for the "beautiful farm maid" thing - most over people would be scarred by smallpox.

    • @hitekkaifighter1825
      @hitekkaifighter1825 8 개월 전 +2

      And tested that hypothesis by infecting a KID with it!!!

    • @joelvanwinkle5976
      @joelvanwinkle5976 8 개월 전 +1

      Thanks Edward Jenner

  • @richtigmann1
    @richtigmann1 8 개월 전 +34

    5:39 "Until one day, humanity said: Enough"
    **Shows birds**

    • @me.280
      @me.280 6 개월 전

      true though💀

    • @me.280
      @me.280 6 개월 전

      the hell im still not “random memer”!!!

  • @scp-kp6kg
    @scp-kp6kg 8 개월 전 +1

    I've seen a Dr. House episode where a person was suspected to have smallpox because they have retrieved an object from a sunken ship, but then it turned out to be another similar disease, but is it theoretically possible to get small pox from an old object that was left in closed space?

  • @jhonthanatos
    @jhonthanatos 8 개월 전

    Thanks for your great work

  • @azdgariarada
    @azdgariarada 8 개월 전 +588

    The idea that there are people out there who see this video as "controversial" saddens me deeply.

    • @MoltenMetal613
      @MoltenMetal613 8 개월 전 +122

      I heard a conversation at a bar with people who were anti-flu and measles vaccination but STILL praised the smallpox vaccine.

    • @tbird81
      @tbird81 8 개월 전 +42

      It's mainly the sponsor you need to be skeptical about "Open Philanthropy"

    • @stapleman007
      @stapleman007 8 개월 전 +12

      The quantity of people wearing face masks in this video was astounding.

    • @Knirin
      @Knirin 8 개월 전 +21

      The answer to “Is this video controversial?” probably depends on the viewers viewpoint of the recent COVID-19 vaccine programs.

    • @dan_loup
      @dan_loup 8 개월 전 +16

      The only counter argument i can see here is that they might be using an extreme situation as advertising for relaxing the regulations on drug safety etc..
      Unless you're some sort of anime villain character that thinks that smallpox was needed to contain the population growth, and that killing it doomed the planet or something.

  • @ericm1373
    @ericm1373 8 개월 전 +14

    I’d never really thought about how a disease only affecting humans could be crucial in actually managing to eradicate it. If something can be contagious to animals as well, you would never be able to get rid of the disease completely, and it could always come back… unless you eradicated it in all possible vectors for the disease.

    • @DaellusKnights
      @DaellusKnights 5 개월 전

      Yeah, that's why anthrax is so persistent... It can lay dormant in SOIL for decades! It's literally impossible to eradicate it completely unless we find a way to immunize the actual Earth to remove all the many vectors for infection... 😳
      BUT! I have hope that we'll somehow find a way just like they eventually did for smallpox. 👍

  • @DoFliesCallUsWalks
    @DoFliesCallUsWalks 7 개월 전 +2

    I love how all the human structures in Kurzgesagt have arms that don't reach their groin lol

  • @rigkashyap5550
    @rigkashyap5550 8 개월 전 +722

    You know, this is proof that when humans come together, we can solve any problem. And with all the problems going around in the world, unity can indeed help save the world..

    • @Idoexist._.
      @Idoexist._. 8 개월 전 +7

      Theres only 2 of that cases hovewer. Stop super-high emissions and to cure smallpox

    • @clintelkins9630
      @clintelkins9630 8 개월 전 +24

      It'd be neat if we actually did

    • @FreePigeon
      @FreePigeon 8 개월 전

      The people in charge don't want unity. You can't make money if there's peace and unity. So we'll keep these endless wars going and continue importing more people than our countries can sustain. Oh and don't forget the race baiting that started just after Occupy Wall Street, complete coincidence though, don't go googling about the mysterious rise in racism politics once the elites learned we knew who was keeping us down.

    • @abdsalamelkhamlichi6677
      @abdsalamelkhamlichi6677 8 개월 전

      Not when we have right wing lunatics.

    • @jonathanodude6660
      @jonathanodude6660 8 개월 전

      not super high emissions, we saved the ozone layer via banning CFCs worldwide.@@Idoexist._.

  • @evodolka
    @evodolka 8 개월 전 +26

    7:21
    Aww, Cowpox looks adorable

  • @FunnyLarvaFamily-lx8xh
    @FunnyLarvaFamily-lx8xh 8 개월 전 +1

    Can we appreciate how they tried their best to make this amazing video for us 💖💖💖

  • @conors4430
    @conors4430 8 개월 전 +17

    Yeah, we are spoiled enough to live in a time where we have dealt with so many medical issues that we can literally afford to believe that they never existed and are conspiracies. When my mum immigrated, she was not allowed in to the country until she could prove that she had a smallpox vaccination. Her friend grew up on a farm and never had the mild reaction. To the vaccine, they didn’t fully understand. Why, then they realised, she had been farming and taking care of cows, her entire life so her body had already reacted or remembered, because it had been exposed to cows on Mass.

  • @chaboof120
    @chaboof120 8 개월 전 +937

    Every time I see a proclamation of a human triumph over a disease, I feel an overwhelming amount of awe and patriotism towards the human race which I'm a part of. It almost brings me to tears every time I see the indomitable will of man brought down like a hammer unto our enemies.

    • @Sk8rGuy5141
      @Sk8rGuy5141 8 개월 전 +1

      It's too bad that within the same human race, there's anti-vaxers and people against immunity of deadly and threatening viruses, claiming the vaccines have "worse" implications. Some people are such idiots.

    • @eoffsock
      @eoffsock 8 개월 전

      Yeah and there are anti-vaxxers. Just imagine, right? A humanity found the way to eliminate the disease, but there are people like "nah it turns me into a cow, I'll better die". And they are still freaking exists.

    • @Steel9k
      @Steel9k 8 개월 전 +15

      Nuclear bomb.
      The real hammer.

    • @IAmebAdger
      @IAmebAdger 8 개월 전

      @@Steel9k A double-sided hammer that the human race uses to hit itself, yes. Rather makes me less patriotic for the human race, that one.

    • @Steel9k
      @Steel9k 8 개월 전

      @@eoffsock
      Don't forget of provaxers.
      Those weirdos claim their vaccines work.
      In the same time they are terrified of unvaccinated peoole, and wage a war against the unvaccinated, against human rights, self determination and against freedom.
      I guess infectious diseases are not the true enemy, since there are still plenty of infectious disease after so many vaccination programmes.
      Provaxers must wage their annoying wars. Is it not strange, mate?

  • @krishnvm1027
    @krishnvm1027 8 개월 전 +34

    5:16 "or you Die" so nonchalantly

  • @davinaambarita2238
    @davinaambarita2238 4 개월 전 +1

    So cool! Can you make a video which discuss thalium and it's poissoning? I think that's really interesting after i watched rotten mango's video abt one of the case

  • @doggo6462
    @doggo6462 8 개월 전 +1

    pretty inspiring quote
    "we killed one monster, we can do it again"
    just gives motivation to if we ever came across another deadly virus we can bring it down together like the other one

    • @Steel9k
      @Steel9k 8 개월 전

      They had motivation to abuse and discriminate hundreds of millions who didn't obey bill gates and the WEF

  • @ayuchanayuko
    @ayuchanayuko 8 개월 전 +38

    The thing with the cow is that the scientist noticed that milkmaids never got smallpox. Thats when he got the idea of cowpox protecting against smallpox.
    It takes presence of mind to notice such a thing.

  • @bakonhair5559
    @bakonhair5559 8 개월 전 +21

    9:14 bro got trolled 💀

  • @aq5426
    @aq5426 8 개월 전 +2

    And the Guinea Worm is almost extinct too, IIRC.

  • @DoFliesCallUsWalks
    @DoFliesCallUsWalks 3 개월 전 +2

    The last part was awesome. Love how Kurzgesagt expresses emotions.

  • @just_kos99
    @just_kos99 8 개월 전 +189

    A biography I read of Catherine the Great of Russia was really awesome. She had her people go around town to town, vaccinating people against smallpox (or whatever form they did.... not sure if it was 'inoculating' or something). She had it done to herself in front of her whole court to show it wasn't a big deal. It's amazing how early on they learned this, after seeing that milkmaids didn't tend to get smallpox 'cause they'd already had the milder cowpox.

    • @pointyheadYT
      @pointyheadYT 8 개월 전 +6

      Yes, it was "inoculating". Vaccines didn't yet exist in the form we have today.

    • @thenatureedits8089
      @thenatureedits8089 8 개월 전

      read about it in the Science museum in London. Thats how that british guy figured out the connection

    • @JESUSCHRIST-ONLYWAYTOHEAVEN
      @JESUSCHRIST-ONLYWAYTOHEAVEN 8 개월 전

      GOD'S STANDARD FOR HEAVEN IS PERFECTION AND ONLY JESUS (THE SON OF GOD/GOD IN THE FLESH) LIVED THAT PERFECT LIFE! HE LAID DOWN HIS LIFE & TOOK THE WRATH OF THE FATHER ON THE CROSS FOR YOUR SINS! GOD IS JUST SO HE MUST PUNISH SIN & HE IS HOLY SO NO SIN CAN ENTER HIS KINGDOM OF HEAVEN. IF YOU ARE IN CHRIST ON JUDGEMENT DAY GOD WILL SEE YOU AS HIS PERFECT SON (SINLESS SINCE YOUR SINS ARE COVERED BY JESUS' OFFERING). YOU CAN ALSO CHOOSE TO REJECT JESUS' GIFT/SACRIFICE & PAY FOR YOUR OWN SIN WITH DEATH (HELL) BUT THAT SEEMS PRETTY FOOLISH! GOD SEES & HEARS EVERYTHING YOU HAVE SAID & DONE. YOU WONT WIN AN ARGUMENT WITH HIM & YOU CANT DEFEND ANY OF YOUR SINS TO HIM. YOU'RE NOT A GOOD PERSON, I'M NOT A GOOD PERSON... ONLY GOD IS GOOD! WE'RE ALL GUILTY WITHOUT ACCEPTING JESUS' SACRIFICE FOR OUR SINS!
      MUHAMMAD DIDN'T DIE FOR YOUR SINS, BUDDHA DIDN'T DIE FOR YOUR SINS, NO PASTOR/NO PRIEST/NO SAINT/NO ANCESTOR DIED FOR YOUR SINS, MARY DIDN'T, THE POPE DIDN'T EITHER, NO IDOLS OR FALSE gods DIED FOR YOUR SINS, NO MUSICIAN OR CELEBRITY DIED FOR YOUR SINS, NO INFLUENCER OR KRplus STAR DIED FOR YOUR SINS, NO SCIENTIST OR POLITICIAN DIED FOR YOUR SINS, NO ATHLETE OR ACTOR DIED FOR YOUR SINS! STOP IDOLIZING & WORSHIPING THESE PEOPLE!
      JESUS CHRIST ALONE DIED FOR YOUR SINS & WAS RESURRECTED FROM THE GRAVE! HE IS ALIVE & COMING BACK VERY VERY SOON WITH JUDGEMENT (THESE ARE END TIMES)! PREPARE YOURSELVES, TURN FROM SIN & RUN TO JESUS! HE KNOWS YOUR PAIN & TROUBLES, HE WANTS TO HEAL & RESTORE YOU! TALK TO HIM LIKE A BEST FRIEND! ASK HIM TO REVEAL HIMSELF TO YOU & HELP YOU TO BELIEVE IF YOU DOUBT! DON'T WAIT TO CRY OUT! NO ONE IS PROMISED TOMORROW! HE LONGS FOR YOU TO INVITE HIM IN, HE LOVES YOU MORE THAN ANY PERSON EVER COULD, HE CREATED YOU!
      Jesus answered, “I am the way and the truth and the life. No one comes to the Father except through me."-John 14:6
      "But whosoever shall deny me before men, him will I also deny before my Father which is in heaven."-Matthew 10:33
      “For the wages of sin is death (hell), but the gift of God is eternal life in Christ Jesus our Lord”-Romans 6:23

    • @HealyHQ
      @HealyHQ 8 개월 전

      @@JESUSCHRIST-ONLYWAYTOHEAVEN WTF is wrong with you?

    • @thenatureedits8089
      @thenatureedits8089 8 개월 전 +2

      @@JESUSCHRIST-ONLYWAYTOHEAVEN La ilaha illallah Muhammadur Rasulullah

  • @darealsherlock8026
    @darealsherlock8026 8 개월 전 +480

    It's cool how Kurzgesagt is not just a youtube channel, it's a bloody institution. They get grants, just like a uni. Absolutely awesome. Keep up the good work guys.

    • @aaronhpa
      @aaronhpa 8 개월 전 +7

      The universities are not for-profit....

    • @peeperleviathan2839
      @peeperleviathan2839 8 개월 전 +66

      @@aaronhpathen why do they charge so much to go if not for profit?

    • @yuh7139
      @yuh7139 8 개월 전 +6

      ​@@aaronhpatell that to my hex

    • @Minurz
      @Minurz 8 개월 전 +33

      ​@@johh55College admins getting another 100k raise while students struggle to afford housing
      the rest should be from taxpayer dollars, not tuition

    • @plarpoon
      @plarpoon 8 개월 전 +23

      Kek.. America moment having to pay for uni

  • @Coop-sg6qc
    @Coop-sg6qc 8 개월 전 +4

    It absolutely amazes me how us humans are able to do so much when United. Humanity may not be the best but it's always amazing to watch us progress

  • @xlynx9
    @xlynx9 8 개월 전 +3

    7:21 cowpox looked really cute.

  • @ziroja
    @ziroja 8 개월 전 +180

    The last outbreak of Variola vera in Europe happened in Yugoslavia in 1972. It was quickly put under control and thousands of people were vaccinated in short time to stop it from spreading.

    • @bigmonkey1254
      @bigmonkey1254 8 개월 전 +17

      Variola: *exists*
      The global medical community: "Contain that motherf**cker!"

    • @lordgarion514
      @lordgarion514 8 개월 전 +1

      The last known natural case of smallpox was in 1977, in Somalia.
      It was declared eradicated from nature in 1980.

  • @pyritenightmare
    @pyritenightmare 8 개월 전 +247

    I'm a bit sad that the way "scientists realized" cowpox could be effective wasn't specifically mentioned (namely, the seeming immunity to the virus displayed by milkmaids). While it was still shown somewhat visually, I don't think many people will notice unless they already know. It's definitely an important part of the story, one that demonstrates that science doesn't just happen and discoveries aren't just made, but that it came from a real place, a known phoenomenon. It may not be as important on a channel meant for people already interested in science, but one of the biggest reasons it's easy for people to distrust it is that they simply don't understand how it integrates into the real world. Bridging that gap, pointing out a situation where scientists saw something already happening and spread the word, is important. It's not a part of the story of smallpox which should be forgotten.

    • @yellowbags
      @yellowbags 8 개월 전 +13

      Well said. Important points!

    • @thesleepinggirl
      @thesleepinggirl 8 개월 전 +3

      Yes, that's what I was thinking, too.

    • @vice.nor.virtue
      @vice.nor.virtue 8 개월 전 +2

      I didn't think that was that essential. The overarching story that we realised we could widthstand cowpox was enough- I just really wish they weree super specific and said "this is the same virus, but the cow-version of it!"
      I also wish they had mentioned that birds, fish, reptiles and hundreds of other mammals have their own version of smallpox

    • @naomi-USA
      @naomi-USA 8 개월 전 +15

      I don't know if it's because of this but in my country we use to call a very lucky person as a "lechero (milkman)" or "lechera (milkmaid)". I wonder if this comes from the times where this people were considered to be lucky for not developing such a terrible disease.

    • @robertbackhaus8911
      @robertbackhaus8911 8 개월 전

      In this case, there was the clue that cowpox lesions looked similar to smallpox lesions, so nature was pointing in a 'look over there, this could be interesting' way. Once someone stated looking at cowpox its neutralizing effects were going to be found.

  • @XalasiaBall
    @XalasiaBall 3 개월 전 +2

    0:23 And to thank the cows, we got rid of rinderpest for them.

  • @cleopalmer5693
    @cleopalmer5693 3 개월 전 +1

    These videos are always so interesting to me! I love them.

  • @LonkABonk
    @LonkABonk 8 개월 전 +337

    This is a lesson that when humanity comes together, we can beat even the most horrible things on earth

    • @JokeswithMitochondria
      @JokeswithMitochondria 8 개월 전 +23

      Sadly we do not come together nowadays

    • @sterlingarcher8041
      @sterlingarcher8041 8 개월 전

      @@JokeswithMitochondriahey dude I was curious about ur ussername so I went ahead and cIicked on ur profiIe. Had a good laugh lol

    • @vkobevk
      @vkobevk 8 개월 전

      yes it was when we could working together
      but we can also weaponized the virus
      so what if russia use its smallpox sample to create a new biological weapon ?
      so in 1978 even if we were in cold war soviet us and china could work together for humanity common good
      i dont see that today, russia turn to be openly hostile to us and we are in logic to be hostile against china, russia and iran

    • @risuyami1468
      @risuyami1468 8 개월 전 +4

      @@JokeswithMitochondriadont worry, we will

    • @AssortedGarbage23
      @AssortedGarbage23 8 개월 전 +1

      The purpose of humanity is to make ourselves the only thing that needs to be feared

  • @purplehaze2358
    @purplehaze2358 8 개월 전 +391

    What unsettles me is that, thus far, smallpox is the _only_ disease that humanity has completely eradicated. This leads me to believe that we do, indeed, have the recourses with which to completely wipe out a fair few illnesses - we just haven't yet.

    • @avpguy11
      @avpguy11 8 개월 전 +1

      With so many more people on the planet, and with so many of them rejecting vaccines, it's unlikely that we will ever completely eradicate another pandemic.

    • @clintelkins9630
      @clintelkins9630 8 개월 전 +27

      *laughs in covid*

    • @HankMFWimbleton
      @HankMFWimbleton 8 개월 전 +169

      me when people refuse to have a needle poke your body to hopefully eradicate a disease

    • @Nixthyo
      @Nixthyo 8 개월 전

      That's cos smallpox only infects humans, so immunizing humans is all that's necessary. A lot of other transmitted diseases are zoonotic and can jump between species, making them harder to eradicate.

    • @kh6853
      @kh6853 8 개월 전 +1

      A few determined idiots can kill a lot of people

  • @stressed_vivi
    @stressed_vivi 7 개월 전 +1

    As a person who chose biology as her field of carrer this video really brought me so much happiness hope ambitions and pride. I cant wait to become a laboratory researcher and help humanity in advancing its biology

  • @frangilbethencourt1006

    delightful video, please continue ☺

  • @tatefox
    @tatefox 8 개월 전 +234

    It still occasionally blows my mind that we are a collection of an untold number of cells all doing there own thing functioning independently. Like when we get sick theres a whole network of immune cells that respond that we aren't even conscious of. These cells have intelligence's of there own. It almost feels like we're walking talking universes to a multitude of microscopic life forms. Freaky when you think about it.

    • @d00mnoodle
      @d00mnoodle 8 개월 전 +47

      All thanks to 'emergence' simple things creating something more complex together. From the quarks to the atoms, to molecules to cells, tissues and organs and eventually you. From you to your local environment, from that to societies to a species. Like letters in a word, a sentence in a book. It's cool that these simple things create such complex outcomes!

    • @glenmcgillivray4707
      @glenmcgillivray4707 8 개월 전

      Folks go on about the perfection of creation.
      I point out auto immune responses and how our bodies defense's can overwhelm our ability to heal trying to fight disease or even injury.
      They tell me it's a lie. I have to point to smallpox. It hits us hard, fast, from within our immune system, breaking the chain of natural responses to illness for profit.
      They claim Smallpox doesn't exist. I point out that was one of Mankinds greatest achievements and we need to do it with Measles, Mumps, Rubella, Whopping Cough and Polio.
      We would only have to defeat each of them once, and our species would never need to face them again.
      And either I get strong support to the idea, because they did their research about how nasty these sicknesses are. Enquiries why we haven't cured the Flu, Cancer, HIV or something else so nebulous and complex that herd immunity is a pain to develop. Or folks who claim they never had these things, so why should they get immunised. Which tells me who I shouldn't hang out with if I don't wish for a secondary infection.
      Every immune cell in our bodies works independently, and complex life has been around so long it developed tools to fight back against disease, heal from it, and continue as it always had. There is a limited number of diseases out there that SPECIFICALLY adapted to our unique methods of defence and existence in the effort of finding a great new place to live. And viruses are uniquely in a position of keeping ahead or the immune response curve or dying out forever.
      But no one remembers how successful the Cold is at spreading and moving on. While HIV is deadly (eventually) but terrible at spreading. While the real threats to our civilization and species are the stuff that kills you, while spreading like wildfire.
      Covid-19 had that potential, to overwhelm our health systems, some nations faltered, some nations endured regardless, and yet others cut the curve and suffered very few fatalities, by keeping the case levels low.
      The variation between global responses, and thus body count internationally, is wildly different not due to climate, but due to how well different strategies to manage these contagious outbreaks worked.
      Covid-19 continues to exist. And if it mutates into something nasty, we might have to do it all again. But now enough people have had it to protect our species and society, hopefully. So it doesn't become the next smallpox.

    • @jacobgoodstone7572
      @jacobgoodstone7572 8 개월 전 +14

      We’re really trillions of little organisms all working together to stay alive

    • @_Wombat
      @_Wombat 8 개월 전 +17

      I think about this a lot. Or should I say, the trillions of cells that comprise my being think about it a lot. It's just cells thinking about cells, atoms pondering atoms, the universe peering into itself.

    • @petert1595
      @petert1595 8 개월 전 +6

      If a cell was as big as a human then a human would be as big as 20 Mount Everests. Imagine a blood cell going like Mach 3 speeds just to get from your feet to your head and back!

  • @vaibhavsingh192
    @vaibhavsingh192 8 개월 전 +61

    “The simple things in life are often the moo-st beautiful."
    - A wise cow.

  • @turtle_lover4213
    @turtle_lover4213 7 개월 전 +4

    In a way it's sad we are not this united as a species anymore. Almost like we need a common enemy to have empathy for one another. No common enemy and we turn on ourselves

    • @davidharrison7072
      @davidharrison7072 7 개월 전

      We do have a common enemy though. Climate change is almost certainly the biggest threat to humanity we've ever faced. Not so much with the unity yet though.

  • @ericcozzens2059
    @ericcozzens2059 7 개월 전

    I love all of your videos they’re amazing have amazing quality! I think it would be a good video idea to talk about tuberculosis. It’s not eradicated yet at all, and I believe it’s still the number 1 infectious killer worldwide. It would be very good if more people were informed about this horrible disease and it’s seriousness. Just an opinion!

  • @dinohall2595
    @dinohall2595 8 개월 전 +187

    "We killed one monster. We can do it again."
    I don't know why such a simple statement manages to give me goosebumps, but it does.

    • @WhoGaveHit
      @WhoGaveHit 8 개월 전 +5

      They gave you goosebumps once, they can do it again

    • @Gaehhn
      @Gaehhn 8 개월 전 +2

      Made me want to rewatch CGP Greys Fable of the Dragon Tyrant again.

    • @reknostarfox4690
      @reknostarfox4690 8 개월 전 +1

      You are goosebumps

    • @getsideways7257
      @getsideways7257 8 개월 전 +2

      They killed one monster, but they can create a new one, maybe even from scratch (pun not intended)... Evolution is blind and still manages to come up with terrifying things. Now imagine you give it the eyes...

    • @AverageNecronEnthusiast
      @AverageNecronEnthusiast 8 개월 전 +1

      @@Gaehhn Respect. Awesome video

  • @purplehaze2358
    @purplehaze2358 8 개월 전 +83

    It was very unsurprising that the last two samples of smallpox were in the laboratories of the US and Russia respectively.

    • @VeiledLingeringSoul
      @VeiledLingeringSoul 8 개월 전 +3

      Yes, I thought so too

    • @bw2082
      @bw2082 8 개월 전 +7

      Of course. Th
      Is was during the cold war and they were the two superpowers.

    • @donsolos
      @donsolos 8 개월 전 +6

      @@bw2082 biological weapons yo

    • @Caedus696
      @Caedus696 8 개월 전 +11

      Yeah and even more concerning knowing one of those two might be unhinged enough to reintroduce the disease to an enemy population.

    • @CaptainMisery86
      @CaptainMisery86 8 개월 전 +8

      The US has also misplaced some samples of it. One guy left it out in the middle of a lab. I think a janitor found it. I think we also had some grad students find a sample while cleaning out a cooler in their school lab.

  • @jacobblue52
    @jacobblue52 8 개월 전

    2:18 its so interesting how a graphic pops up saying this isn’t completey understood and is a rough draft, but you never see that in space videos. Like humans jn a way know more about the larger things in the universe that are beyond us more than our own body and cells. Shows the real scale of small things and how difficult it is to learn and observe from

  • @swaminathanthegreatest2407

    I always cry in happiness whenever there is a happy ending to the story.

  • @usonumabeach300
    @usonumabeach300 8 개월 전 +149

    Couple things I've picked up over the years pertinent to this video: the ccr5 delta 32 gene mutation is believed by scientists to have developed in Northern Europeans as a response to this virus or one very similar. The way I remember reading it, there's A cell organelle that protrudes from our cells that HIV, Small Pox, and the Black Plague use to infiltrate our cells. This mutation recesses this organelle, making it much, much more difficult for these viruses to get in. If you have 2 copies of this mutation, you're effectively immune to these viruses. The only HIV patients to be truly cured of HIV did so upon receiving marrow donations from people with the double mutation.

    • @blunderingfool
      @blunderingfool 8 개월 전 +21

      Oh cool, I have paranoid organelles, neat!

    • @Griffindeleon004
      @Griffindeleon004 8 개월 전 +1

      ​@@blunderingfoolu a cute derg lol

    • @blunderingfool
      @blunderingfool 8 개월 전 +2

      @@Griffindeleon004 I keep getting compliments about the dragon today. :P That coat is one I used to own, back when I got the art commissioned.

    • @Griffindeleon004
      @Griffindeleon004 8 개월 전 +2

      @@blunderingfool coats are awesome, I have camel colored great coat myself.

    • @kickflop21
      @kickflop21 8 개월 전 +4

      Delta cxcr4 gene also gives immunity to HIV as well 😊

  • @adamlivesay1973
    @adamlivesay1973 8 개월 전 +57

    Imagine being a species that eradicated one of its biggest killers, only for it to possibly come back because there are too many members of your species who dont believe the records your species has kept.

    • @JESUSCHRIST-ONLYWAYTOHEAVEN
      @JESUSCHRIST-ONLYWAYTOHEAVEN 8 개월 전 +1

      GOD'S STANDARD FOR HEAVEN IS PERFECTION AND ONLY JESUS (THE SON OF GOD/GOD IN THE FLESH) LIVED THAT PERFECT LIFE! HE LAID DOWN HIS LIFE & TOOK THE WRATH OF THE FATHER ON THE CROSS FOR YOUR SINS! GOD IS JUST SO HE MUST PUNISH SIN & HE IS HOLY SO NO SIN CAN ENTER HIS KINGDOM OF HEAVEN. IF YOU ARE IN CHRIST ON JUDGEMENT DAY GOD WILL SEE YOU AS HIS PERFECT SON (SINLESS SINCE YOUR SINS ARE COVERED BY JESUS' OFFERING). YOU CAN ALSO CHOOSE TO REJECT JESUS' GIFT/SACRIFICE & PAY FOR YOUR OWN SIN WITH DEATH (HELL) BUT THAT SEEMS PRETTY FOOLISH! GOD SEES & HEARS EVERYTHING YOU HAVE SAID & DONE. YOU WONT WIN AN ARGUMENT WITH HIM & YOU CANT DEFEND ANY OF YOUR SINS TO HIM. YOU'RE NOT A GOOD PERSON, I'M NOT A GOOD PERSON... ONLY GOD IS GOOD! WE'RE ALL GUILTY WITHOUT ACCEPTING JESUS' SACRIFICE FOR OUR SINS!
      MUHAMMAD DIDN'T DIE FOR YOUR SINS, BUDDHA DIDN'T DIE FOR YOUR SINS, NO PASTOR/NO PRIEST/NO SAINT/NO ANCESTOR DIED FOR YOUR SINS, MARY DIDN'T, THE POPE DIDN'T EITHER, NO IDOLS OR FALSE gods DIED FOR YOUR SINS, NO MUSICIAN OR CELEBRITY DIED FOR YOUR SINS, NO INFLUENCER OR KRplus STAR DIED FOR YOUR SINS, NO SCIENTIST OR POLITICIAN DIED FOR YOUR SINS, NO ATHLETE OR ACTOR DIED FOR YOUR SINS! STOP IDOLIZING & WORSHIPING THESE PEOPLE!
      Jesus answered, “I am the way and the truth and the life. No one comes to the Father except through me."-John 14:6
      "But whosoever shall deny me before men, him will I also deny before my Father which is in heaven."-Matthew 10:33
      “For the wages of sin is death (hell), but the gift of God is eternal life in Christ Jesus our Lord”-Romans 6:23

    • @handleAlreadyUsed
      @handleAlreadyUsed 8 개월 전 +13

      @@JESUSCHRIST-ONLYWAYTOHEAVENok, this is not a video about religion, and you are still praising god since he saved your life, while the smallpox scientists could have been the ones who are the reason why you are born. Please do not insult other religions, but acknowledge them. I do not mean to be rude to you or your religion, but the scientists may have saved your life.

    • @hakimdiwan5101
      @hakimdiwan5101 8 개월 전 +7

      Fortunately those Darwin award recipients mostly are from one country.

    • @ZebraOnYourNose
      @ZebraOnYourNose 8 개월 전

      It's further evidence that the human mind is incredibly stubborn, selfish, and gullible

    • @reverendgaddy2435
      @reverendgaddy2435 8 개월 전 +1

      no need to imagine, unfortunately. that's the actual world we live in...

  • @TranNguyen9
    @TranNguyen9 8 개월 전

    Wow such an amazing video!! I did not know how recent the small box vaccine actually was so you know something new every day!

  • @FerrexShelby-ed9hg
    @FerrexShelby-ed9hg 25 일 전 +1

    "All made possible by, cows."
    killed me 💀

  • @jamalzahr2689
    @jamalzahr2689 8 개월 전 +235

    This is the side of KRplus I wish to stay, there aren't many informational KRplusrs out there who can deliver a spot on video with all facts within accuracy, paired with great animations. Keep it up Kurzgesagt!

    • @RaineeVR
      @RaineeVR 8 개월 전 +2

      Agreed, I also like how if when they do make a mistake they do their best to correct the information which is rare but does happen

    • @rehkloo6
      @rehkloo6 8 개월 전

      rational animations is a animated fact youtube channel!

    • @rapidlemon906
      @rapidlemon906 8 개월 전 +1

      ​@RaineeVR the last video was a train wreak and I haven't seem them correct or say anything, but at least this one seems a lot better (that sounds kinda mean I don't mean it in that way, i would also take the videos where they receive grants with a grain of salt because the last video the sponsors definitely had a say in the script. again sounds mean i dont mean it like that 😊)

    • @tbird81
      @tbird81 8 개월 전

      They're all sponsored by some of the most shady organisations now.

  • @varunapathak2096
    @varunapathak2096 8 개월 전 +70

    I don't know why this made me so emotional especially towards the end.
    Humanity indeed can do seemingly impossible things together but we are separated by the boundaries we ourselves created. We are our own roadblock.

    • @Daft_Vader
      @Daft_Vader 8 개월 전 +8

      ​@content_enjoyer4458I'd say that's the opposite of naive

    • @Darkcamera45
      @Darkcamera45 8 개월 전 +8

      @@content_enjoyer4458no that view is very wise anything but naive

    • @Tapion3388
      @Tapion3388 8 개월 전 +3

      @@content_enjoyer4458 Care to explain why this view is naive? I think it's merely a fact that humanity could've achieved a lot more if we wouldn't fight ourselves for dubios reasons...

  • @EdgarVasquez-rd8dr
    @EdgarVasquez-rd8dr 5 개월 전 +6

    Can we just talk about how cute the Cowpox design is?

  • @jaimebergner
    @jaimebergner 8 개월 전 +230

    I am old enough to have gotten vaccinated against Smallpox in school. Also the "sugar" vaccine (against Polio). I found the "scraping" easier pain wise than the Tetanus shots I have received over my life time. I remember having a sore arm for several days and the feeling of "coming down with something" for a short time. To this day I like the two Smallpox vaccine scars on my upper arm. They give me a good, safe feeling.

    • @danilooliveira6580
      @danilooliveira6580 8 개월 전

      the vaccine scarring (also BCG's) is probably what traumatizes a lot of kids with vaccines and make them so scared of being vaccinated, because most vaccines actually don't hurt at all.

    • @seekingfinding6204
      @seekingfinding6204 8 개월 전 +7

      I remember the sugar cube! Nice to know I didn't have to worry about all those deadly illnesses.

    • @sichan1263
      @sichan1263 8 개월 전

      Unfortunately, the smallpox vaccine only protects you for around 10 years. The last person in Britain to die of smallpox in 1978, the Birmingham medical school lab technician Janet Parker, was actually vaccinated. She died because research was still being carried out on live variola in the lab below her, despite all requests to destroy any samples of the virus worldwide, and the air from that lab vented into hers. Shortly after she died, the head of Birmingham Medical School, Henry Benson, who had authorised the work on the virus, killed himself. My Dad knew him.

    • @frozenfeet4534
      @frozenfeet4534 8 개월 전 +2

      thank you for your service and may the next generations have fewer anti-vaxxers than the ones before

    • @neurochaotic
      @neurochaotic 8 개월 전 +1

      The sugar cube sucked! Tasted like shoe polish.
      I'm also one of the last in my country to have received the smallpox jab; for whatever reason it was given on my thigh (the mark is still there, plain as day). I received a bunch of vax before my 5th birthday, don't remember much about them but I do recall once getting what is called a "kiiltokuva" (lit. "shiny picture"; a type of glossy embossed scrapbook picture) in my language; they were popular at the time and doctors would frequently give those to kids who were afraid of needles. It was an orange kitten playing with a blue ball of yarn. It was one of my most treasured possessions.

  • @Ingenatic
    @Ingenatic 8 개월 전 +36

    I lived in the small town of Berkeley, UK for years. It always fascinated me that Edward Jenner (the father of the vaccine and who discovered the link with cowpox) lived in the house opposite. His house is now a museum

  • @christacker5098
    @christacker5098 8 개월 전

    Great video =) Thanks a lot :)

  • @paprus5972
    @paprus5972 8 개월 전 +1

    Smallpox, Humankind's greatest rival. Now reduced to plushies.

  • @CallieC143
    @CallieC143 8 개월 전 +136

    Honestly it’s so invigorating to see that the world has worked together before. We can make a world that’s so much better when we work together